Publications

Coleman CM, Frieman MB. Growth and Quantification of MERS-CoV Infection. Curr Protoc Microbiol. 2015 May 1;37:15E.2.1-9.

Gralinski LE, Ferris MT, Aylor DL, Whitmore AC, Green R, Frieman MB, Deming D, Menachery VD, Miller DR, Buus RJ, Bell TA, Churchill GA, Threadgill DW, Katze MG, McMillan L, Valdar W, Heise MT, Pardo-Manuel de Villena F, Baric RS. Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross. PLoS Genet. 2015 Oct 9;11(10):e1005504.

Taylor J, Coleman C, Postel S, Siske J, Bernbaum J, Venkataraman R, Sundberg S and Frieman MB. Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference. Journal of Virology. September 2015.

Kristen P, Coleman C, Mujica A, Kamat V, Badithe A, Fairhurst J, Hunt C, Strein J, Berrebi A, Babb R, Chen G, Lai K, Huang T, Olson W, Stahl N, Frieman M. Pre- and post-exposure efficacy of fully human VelocImmune® antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection. PNAS. 2015 June 15.

McSweegan E, Weaver SC, Lecuit M, Frieman M, Morrison TE, Hrynkow S.The Global Virus Network: Challenging chikungunya. Antiviral Res. 2015 Aug;120:147-52. Epub 2015 Jun 10. Review

Nita-Lazar M, Banerjee A, Feng C, Amin MN, Frieman MB, Chen WH, Cross AS, Wang LX, Vasta GR. Desialylation of airway epithelial cells during influenza virus infection enhances pneumococcal adhesion via galectin binding. Mol Immunol. 2015 Jan 15;65(1):1-16. PMID: 25597246.

Astry B, Venkatesha SH, Laurence A, Christensen-Quick A, Garzino-Demo A,Frieman MB, O’Shea JJ, Moudgil KD. Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory Tells in the target organ. Clin Immunol. 2015 Apr;157(2):228-38. Epub 2015 Feb 7. PubMed PMID: 25660987.

Mojica SA, Hovis KM, Frieman MB, Tran B, Hsia RC, Ravel J, Jenkins-Houk C, Wilson KL, Bavoil PM. SINC, a type III secreted protein of Chlamydia psittaci, targets the inner nuclear membrane of infected cells and uninfected neighbors.Mol Biol Cell. 2015 May 15;26(10):1918-34. Epub 2015 Mar 18. PubMed PMID: 25788290

Frieman M, Sola I, Enjuanes L.  Virus Research. Forward. Nidoviruses II. Virus Research. 2015  April 16;202:1-2.

Matthews K, Schafer A, Pham A and M.B. Frieman. The SARS Coronavirus Papain Like Protease can inhibit IRF3 at a post activation step that requires deubiquitination activity. Virology Journal 2014, 11:209.

J Kindrachuk, B Ork, B Hart, S Mazur, M Holbrook, M Frieman, D Traynor, R Johnson, J Dyall, J Kuhn, G Olinger, L Hensley, and P Jahrling. The Antiviral Potential of ERK/MAPK and PI3K/AKT/mTOR Signaling Modulation for MERS-CoV Infection as Identified by Temporal Kinome Analysis. Antimicrob Agents Chemother. 2014 Dec 8. PMID: 25487801.

Coleman CM, Frieman MB. Treating MERS-CoV during an outbreak. Lancet Infectious Diseases. 2014, Sept 29. pii: S1473-3099(14)70939-9. PMID: 25278219

Matthews, K. L., C. M. Coleman, Y. van der Meer, E. J. Snijder, and M. B. Frieman. 2014. The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signaling. J Gen Virol 95:874-82. PubMed PMID: 24443473; PubMed Central PMCID: PMC3973478.

Li, J., W. Sun, P. B. Subrahmanyam, C. Page, K. M. Younger, I. V. Tiper, M. Frieman, A. S. Kimball, and T. J. Webb. 2014. NKT Cell Responses to B Cell Lymphoma. Med Sci (Basel) 2:82-97. PubMed PMID: 24955247; PubMed Central PMCID: PMC4063678.

Ladner, J. T., B. Beitzel, P. S. Chain, M. G. Davenport, E. F. Donaldson, M. Frieman, J. R. Kugelman, J. H. Kuhn, J. O’Rear, P. C. Sabeti, et al. 2014. Standards for sequencing viral genomes in the era of high-throughput sequencing. MBio 5:e01360-14. PubMed PMID: 24939889; PubMed Central PMCID: PMC4068259.

Kim, W. K., D. Jain, M. D. Sanchez, C. J. Koziol-White, K. Matthews, M. Q. Ge, A. Haczku, R. A. Panettieri, Jr., M. B. Frieman, and C. B. Lopez. 2014. Deficiency of melanoma differentiation-associated protein 5 results in exacerbated chronic postviral lung inflammation. Am J Respir Crit Care Med 189:437-48. PubMed PMID: 24417465; PubMed Central PMCID: PMC3977719.

Hart, B. J., J. Dyall, E. Postnikova, H. Zhou, J. Kindrachuk, R. F. Johnson, G. G. Olinger, Jr., M. B. Frieman, M. R. Holbrook, P. B. Jahrling, L. Hensley and M.B. Frieman. 2014. Interferon-beta and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays. J Gen Virol 95:571-7. PubMed PMID: 24323636; PubMed Central PMCID: PMC3929173.

Frieman, M. 2014. The art of war: battles between virus and host. Curr Opin Virol 6:76-7. PubMed PMID: 24886699.

Dyall, J., C. M. Coleman, B. J. Hart, T. Venkataraman, M. R. Holbrook, J. Kindrachuk, R. F. Johnson, G. G. Olinger, Jr., P. B. Jahrling, M. Laidlaw, Hensley L, and Frieman M. 2014. Repurposing of clinically developed drugs for treatment of middle East respiratory syndrome coronavirus infection. Antimicrob Agents Chemother 58:4885-93. PubMed PMID: 24841273.

Coleman, C. M., K. L. Matthews, L. Goicochea, and M. B. Frieman. 2014. Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus. J Gen Virol 95:408-12. PubMed PMID: 24197535; PubMed Central PMCID: PMC3917065.

Coleman, C. M., Y. V. Liu, H. Mu, J. K. Taylor, M. Massare, D. C. Flyer, G. M. Glenn, G. E. Smith, and M. B. Frieman. 2014. Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice. Vaccine 32:3169-74. PubMed PMID: 24736006; PubMed Central PMCID: PMC4058772.

Coleman, C. M., and M. B. Frieman. 2014. Coronaviruses: important emerging human pathogens. J Virol 88:5209-12. PubMed PMID: 24600003; PubMed Central PMCID: PMC4019136.

Adedeji, A. O., K. Singh, A. Kassim, C. M. Coleman, R. Elliott, S. R. Weiss, M. B. Frieman, and S. G. Sarafianos. 2014. Evaluation of SSYA10-001 as a Replication Inhibitor of Severe Acute Respiratory Syndrome, Mouse Hepatitis, and Middle East Respiratory Syndrome Coronaviruses. Antimicrob Agents Chemother 58:4894-8. PubMed PMID: 24841268.

Coleman, C. M., and M. B. Frieman. 2013. Emergence of the Middle East respiratory syndrome coronavirus. PLoS Pathog 9:e1003595. PubMed PMID: 24039577; PubMed Central PMCID: PMC3764217.

Induction of alternatively activated macrophages enhances pathogenesis during SARS Coronavirus infection.  Page C, Goicochea L, Matthews K, Zhang Y, Klover P, Holtzman M, Hennighausen L, and Frieman M.  J Virology, 2012 Sept 26.

Evidence Supporting a Zoonotic Origin of Human Coronavirus Strain NL63.  Huynh J, Li S, Yount B, Smith A, Sturges L, Olsen JC, Nagel J, Johnson JB, Agnihothram S, Gates JE, Frieman MB, Baric RS, Donaldson EF.    J Virol. 2012 Sep 19.

Yeast Based Small Molecule Screen for Inhibitors of SARS-CoV.  Frieman M, Basu D, Matthews K, Taylor J, Jones G, Pickles R, Baric R and Engel D.   PLoS One. 2011;6(12):e28479. Epub 2011 Dec 2.

Molecular Determinants of SARS Coronavirus Pathogenesis and Virulence in Young and Aged Mouse Models of Human Disease.  Frieman M, Yount B, Agnihothram S, Page C, Donaldson E, Roberts A, Vogel L, Smock S,Scorpio D, Subbarao K, and Baric R.   J Virol. 2012 Jan;86(2):884-97. Epub 2011 Nov 9.

Potential role for alternatively activated macrophages in the secondary bacterial infection during recovery from influenza.  Chen W, Toapanta F, Shirey K, Zhang L, Giannelou A, Page C, Frieman MB, Vogel S, Cross AS.   Immunol Lett. 2012 Jan 30;141(2):227-34. Epub 2011 Oct 20.

Genetic analysis of complex traits in the emerging collaborative cross.  Aylor DL, Valdar W, Foulds-Mathes W, Buus RJ, Verdugo RA, Baric RS, Ferris MT, Frelinger JA, Heise M, Frieman MB, Gralinski LE, Bell TA, Didion JD, Hua K, Nehrenberg DL, Powell CL, Steigerwalt J, Xie Y, Kelada SN, Collins FS,Yang IV,Schwartz DA, Branstetter LA, Chesler EJ, Miller DR, Spence J, Liu EY, McMillan L, Sarkar A, Wang J, Wang W, Zhang Q, Broman KW, Korstanje R, Durrant C, Mott R, Iraqi FA, Pomp D, Threadgill D, Pardo-Manuel de Villena F, Churchill GA.  Genome Res. 2011 Mar 15. 

Integrative deep sequencing of the mouse lung transcriptome reveals differential expression of diverse classes of small RNAs in response to respiratory virus infection.  Peng X, Gralinski L, Ferris M, Frieman M, Thomas M, Proll S, Korth M, Heise M, Luo S, Schroth G, Tumpey T, Baric R & Katze M.  MBio. 2010 Oct 26;1(5). pii: e00206-10.

Unique signatures of long non-coding RNA expression in response to virus infection and altered innate immune signaling.  Peng X, Gralinski L, Armour C, Ferris M, Thomas M, Proll S, Bradel-Tretheway B, Korth M, Castle J, Biery M, Bouzek H, Haynor D, Frieman M, Heise M, Raymond C, Baric R and Katze M.   MBio. 2010 Oct 26;1(5). pii: e00206-10.

Metagenomic analysis of the Virome of three North American Bat Species : Viral Diversity between Different Bat Species that Share a Common Habitat.  Donaldson E, Haskew A, Gates JE, Huynh J, Moore C, Frieman M.  Journal of Virology, Dec 2010;84(24):13004-18.

Small molecule inhibitors of the SARS-CoV NSP15 endoribonuclease.  Ortiz-Alcantara J, Bhardwaj K, Palaninathan S, Frieman M, Baric RS, and Kao CC.   Virus Adaptation and Treatment.  2010:2 1-9.

Transcriptomic analysis reveals a mechanism for a pre-fibrotic phenotype in STAT1 knockout mice during SARS Coronavirus infection.   Zornester* GA, Frieman* MB, Rosenzweig E, Korth MJ, Page C, Baric RS and Katze MG.  Journal of Virology, 2010 Aug 11.  PMID: 20702617.

SARS-CoV pathogenesis is regulated by a STAT1 dependent but a type I, II and III interferon receptor independent mechanism.   Frieman MB, Chen J, Morrison TE, Whitmore A, Funkhouser W, Ward JM, Lamirande EW, Roberts A, Heise M, Subbarao K, Baric RS.  PLoS Pathog. 2010 Apr 8;6(4). PMID: 20386712.

Escape from human monoclonal antibody neutralization affects in vitro and in vivo fitness of severe acute respiratory syndrome coronavirus.  Rockx B, Donaldson E, Frieman MB, Sheahan T, Corti D, Lanzavecchia A, Baric RS.  J Infect Dis. 2010 Mar 15;201(6):946-55.  PMID: 20144042

The ORF3a protein of SARS-CoV Promotes Membrane Rearrangement and Cell Death. Freundt EC, Yu L, Goldsmith CS, Welsh S, Cheng A, Yount B, Liu W, Frieman MB, Buchholz UJ, Screaton GR, Lippincott-Schwartz J, Zaki SR, Xu XN, Baric RS, Subbarao K, Lenardo MJ.  J Virol. 2009 Nov 4.  PMID: 19889773.

A new mouse adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo. Day CW, Baric R, Cai SX, Frieman MB, Kumaki Y, Morrey JD, Smee DF, Barnard DL.  Virology. 2009 Oct 21.  PMID: 19853271

Early Upregulation of ARDS Associated Cytokines Promote Lethal Disease in an Aged Mouse Model of SARS-CoV Infection.  Rockx B, Baas T, Zornetzer GA, Haagmans B, Sheahan T, Frieman MB, Dyer MD, Teal TH, Proll S, van den Brand J, Baric R, Katze MG. Journal of Virology, July 2009. PMID 19420084.

SARS Coronavirus Papain-Like Protease Ubiquitin-like domain and Catalytic domain regulate antagonism of IRF3 and NFkB signaling.  Frieman M, Ratia K, Johnston RE, Mesecar AD, Baric RS. J Virol. 2009 July.  PMID 19369340.

Mechanisms of SARS Pathogenesis and Innate Immune Modulation.  Frieman MB and Baric R.  Microbiol Mol Biol Rev. 2008 Dec;72(4):672-85.  PMID 19052324.

Novel influenza virus NS1 antagonists block replication and restore innate immune function.  Basu D, Walkiewicz MP, Frieman M, Baric RS, Auble DT, Engel DA.  J Virol. 2009 Feb;83(4):1881-91. PMID 19052087.

The SARS coronavirus evades antiviral signaling: role of nsp1 and rational design of an attenuated strain.  Wathelet W, Frieman MB, and Baric R.  J Virol. 2007 Nov;81(21):11620-33. PMID 17715225.

Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane.  Frieman MB, Yount B, Heise M, Davis N, Kopecky-Bromberg S, Johnston R, Palese P and Baric R.   J Virol. 2007 Sep;81(18):9812-24. PMID 17596301.

SARS Coronavirus and Innate Immunity.  Frieman, MB, Heise, M., and Baric RS.  Virus Research.  2008 Apr;133(1):101-12. PMID 17451827.

SARS Coronavirus Proteins ORF 3b, ORF 6 and Nucleocapsid Function as Interferon Antagonists.  Kopecky-Bromberg SA, Martinez-Sobrido L, Frieman M, Baric RS, Palese P.  J Virol. 2006 Nov 15. PMID 17108024.

SARS coronavirus vaccine development.   Baric RS, Sheahan T, Deming D, Donaldson E, Yount B, Sims AC, Roberts RS, Frieman MB, Rockx B.  Adv Exp Med Biol. 2006;581:553-60. PMID 17037597.

SARS coronavirus accessory ORFs encode luxury functions.   Frieman MB, Yount B, Sims AC, Deming DJ, Morrison TE, Sparks J, Denison M, Heise M, Baric RS.  Adv Exp Med Biol. 2006;581:149-52. PMID 16282490.

Severe acute respiratory syndrome coronavirus group-specific open reading frames encode nonessential functions for replication in cell cultures and mice.  Yount B, Roberts RS, Sims AC, Deming D, Frieman MB, Sparks J, Denison MR, Davis N, Baric RS.  Journal of Virology. 2005 Dec;79(23):14909-22. PMID 16282490.

Glycan microarray analysis of Candida glabrata adhesin ligand specificity.  Zupancic ML, Frieman M, Smith D, Alvarez RA, Cummings RD, Cormack BP. Mol Microbiol. 2008 May;68(3):547-59. PMID 18394144.

Multiple sequence signals determine the distribution of glycosylphosphatidylinositol proteins between the plasma membrane and cell wall in Saccharomyces cerevisiae. Frieman MB, Cormack BP.  Microbiology 150: 3105-3114. PMID 15470092.

The omega site sequence of GPI-anchored proteins in S. cerevisiae can determine distribution between the membrane and the cell wall.  Frieman MB, Cormack BP. Molecular Microbiology.  2003 Nov; 50(3): 883-896. PMID 14617149.

Modular domain structure in the Candida glabrata adhesin Epa1p, a beta1,6 glucan-cross-linked cell wall protein. Frieman MB, McCaffery JM, Cormack BP.Molecular Microbiology. 2002 Oct; 46(2):479-92. PMID 12406223.

A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes. Strichman-Almashanu LZ, Lee RS, Onyango PO, Perlman E, Flam F, Frieman MB, Feinberg AP. Genome Research. 2002 Apr;12(4):543-54. PMID 11932239.

RNA polymerase I transcription in a Brassica interspecific hybrid and its progenitors: Tests of transcription factor involvement in nucleolar dominance. Frieman M, Chen ZJ, Saez-Vasquez J, Shen LA, Pikaard CS.Genetics. 1999 May;152(1):451-60. PMID 10224274.